Table 2 Comparison of Pittsburgh sleep quality, insomnia severity score, and plasma estradiol level pre- and post-treatment in control and study groups

Pittsburgh sleep quality score (Median (IQR)

 Pre-treatment

12.00 (10.25–14.00)

11.00 (10.00–13.75)

0.746 ^NS

-0.324^b

 Post-treatment

8.00(7.00–9.00)

6.00 (5.00–7.00)

0.001*

-3.396^b

 P value

 < 0.001*

 < 0.001*

 Z-Score

-4.666^a

-4.651^a

Insomnia severity score

 Pre-treatment

17.00 (15.25–22.00)

20.00 (16.00–22.75)

0.489 ^NS

-0.691^b

 Post-treatment

14.00 (12.25–19.00)

12.50 (10.00–16.00)

0.021*

-2.315 ^b

 P value

 < 0.001*

 < 0.001*

 Z-Score

-4.678^a

-4.646^a

Plasma Estradiol level (pg/ml)

 Pre-treatment

8.95 (6.55–10.88)

7.15 (5.35–9.90)

-1.600b

0.110 ^NS

 Post-treatment

8.95 (6.55–10.95)

7.50 (5.40–9.98)

-1.345b

0.179 ^NS

 P value

0.059 ^NS

0.001*

 Z-Score

-1.890a

-3.436a