An exploratory cohort study of serum estradiol, testosterone, osteoprotegerin, interleukin-6, calcium, and magnesium as potential biomarkers of cervical spondylosis

Bulletin of Faculty of Physical Therapy

Table 2 Correlation between PI, NDI, and the biomarkers (n = 80)

Parameters		NDI	OPG	IL-6	E2	TES	Ca	Mg
PI	r statistics	0.896	0.385	0.190	− 0.163	− 0.032	0.026	− 0.099
PI	p value	< 0.001^*	< 0.001^*	0.091	0.149	0.781	0.816	0.384
NDI	r statistics		0.402	0.235	− 0.162	− 0.145	− 0.025	− 0.114
NDI	p value		< 0.001^*	0.036^*	0.151	0.201	0.827	0.315
OPG	r statistics			0.084	0.241	− 0.451	− 0.024	0.057
OPG	p value			0.461	0.032^*	< 0.001^*	0.830	0.614
IL-6	r statistics				0.096	− 0.295	− 0.239	− 0.088
IL-6	p value				0.399	0.008^*	0.033^*	0.436
E2	r statistics					− 0.701	0.012	0.110
E2	p value					< 0.001^*	0.916	0.330
TES	r statistics						0.089	− 0.035
TES	p value						0.431	0.756
Ca	r statistics							− 0.129
Ca	p value							0.255

PI Pain intensity, measured with the numeric pain rating scale (NPRS), NDI Neck disability index, OPG Osteoprotegerin, IL-6 Interleukin-6, E2 Estradiol, TES Testosterone, Ca Serum calcium, Mg Serum magnesium
^*Pearson correlation (r) was significant at p < 0.05 level (2-tailed)