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Table 2 Outcome measurement, interventions, and results of the articles

From: The effects of closed kinetic chain exercise on pain and physical function in patients with knee osteoarthritis: a narrative review

Author

Objectives

Participant

Inclusion criteria

Study design

Intervention

Duration

Tools

Impression

Journal name, country, & year

Experimental

Control

Dincer, Aribal, Saygin, Incedayi & Rodop [15]

To assess the effectiveness of CKEs on the joint cartilage in subjects with grade I–III knee OA

Total 35 patients

EG = 19

CG = 16

Subjects with grade I–III OA

Age between 40 and 60 years

ACRC criteria were enrolled

RCT

Experimental group (EG):

CKCEs

TENS

Hot-pack

Control group (CG):

TENS

Hot-pack

30-min exercise regimen weekly 5 sessions for a 12-week duration

VAS

WOMAC

MRI

Results displayed no great outcome of CKCE on the cartilage volume or morphology of the OA Knee

Turkey Journal of Physical Medicine and Rehabilitation

Turkey (2016)

Adegoke, Sanya, Ogunlade, & Olagbegi [16]

To evaluate and compare the effectiveness of OKCE and CKCE on pain, function, and ROM of patients with knee OA

Total 29 subjects

OKCE = 15

CKCE = 14

Both sexes of single or both OA knees

Grade II based on the KLC system

ACRC for classification of knee OA

Age 38 years and above

RCT

OKCEs

Quadriceps setting

SLR

Full-arc extension

CKCEs

Quads setting

Mini-squats

Step-up & down

Wall slides with a weight

10 repetitions in each session for 8-week duration

VAS

FIQ

Half-circle universal Goniometer

Both chain exercise regimens have comparable impacts on pain, capacity, and ROM of OA knee

Baltic Journal of Health and Physical Activity

Nigeria (2019)

Olagbegi, Adegoke & Odole [2]

To compare the effects of OKCEs, CKCEs, and CCEs on pain and physical function in OA knee

Total 79 participants

OKCE = 26

CKCE = 26

CCE = 27

Both sexes of single or both OA knees

Grade II is based on the KLC system

ACRC for classification of knee OA

RCT

OKCEs

Quadriceps setting

SLR, full-arc extension

Cycling

in the air

CKCEs

Quadriceps setting

Wall slides

Step-up & down

CCEs:

OKCEs

 + 

CKCEs

3 times per week

12-week duration

VAS Scale

IKHOAM scale

CKCEs are more fruitful than OKCEs for relieving pain during walking

Bangladesh Journal of Medical Science

Bangladesh (2016)

Nahayatbin et.al. [17]

This study aimed to investigate and compare the effectiveness of Tai Chi and CKCEs on patients with knee OA

Total 48 patients

CKCE = 16, TCE = 16

No Rx = 16

Knee OA

Age: 45–65 years

Grades II–III based on the KLC system & grade III (Oxford scale)

RCT

CKCE:

Standard physical therapy

CKCE

Static stretching

TCE:

Standard physical therapy

Tai Chi warm-up and cool-down and 6-form of the yang style of TCEs

No Rx:

Standard physical therapy only

12 sessions of exercises in 4 weeks

6 MWT & KOOS Questionnaire

Both TCE and CKCE relieved pain, improved ADL, sports and recreational activity, and increased 6-min walking distance in patients with knee OA

IRCMJ

Iran (2018)

Olagbegi, Adegoke & Odole [12]

To investigate the effects of OKCE, CKCE & CCE on quads muscle power and thigh girdle in patients with OA knee

Total 96 participants

OKCE = 32

CKCE = 32

CCE = 32

Mild to moderate knee OA

Both sexes of single or both OA knees

Grade II based on the KLC system

ACRC for classification of knee OA

Crepitation & morning stiffness

RCT

OKCEs

Quadriceps setting

Cycling in the air

SLR with weight

Full-arc extension

CKCEs

Quadriceps setting

Wall slides with a weight

Step up and down with the weight

CCEs:

OKCEs + CKCEs

10 repetitions per session

12-week duration

Cable tensiometer

Tape measure

Each of the three therapy regimens is fruitful and demonstrates equivalent impacts on quads muscle power in knee OA

Archives of physiotherapy

South Africa (2017)

Özüdoğru & Gelecek [18]

To evaluate the effects of OKCE and CKCE on pain, physical function, muscular strength, and QOL in knee OA patients

Total 60 participants

OKCE = 20

CKCE = 20

CG = 20

Age range of 45 to 75 years

Unilateral knee OA grades I–II

At least 3 months with pain

RCT

OKCEs

Four-way straight leg rises

Concentric quadriceps

Maximal knee extension

CKCEs

Mini squat

Sit to stand

Anterior lunge and

3-side step-up exercise

CG

Home exercise regimen through phone call

Exercised thrice weekly for 12 weeks duration

VAS

WOMAC

Isokinetic test

SF-36

Both groups are helpful in relieving knee pain and reducing stiffness and improving muscle power and CKCE is the safest for low-grade knee OA patients

Revista da Associação Médica Brasileira

Brazil (2023)

  1. ACRC American College of Rheumatology Criteria, CCE combined chain exercise, CKE close kinetic exercise, CKCE close kinetic chain exercise, FIQ Functional Index Questionnaire, IKHOAM Ibadan Knee/Hip Osteoarthritis Outcome Measure, KOOS Knee Injury & Osteoarthritis Outcome Score, MRI magnetic resonance imaging, OKC open chain exercises, OKCE open kinetic chain exercise, RCT randomized clinical trial, ROM range of motion, SLR straight leg raise, TCE Thai Chai exercise, VAS visual analog scale, WOMAC Western Ontario McMaster University Osteoarthritis Index