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Impact of chronic kidney disease on anthropometric profile, health-related quality of life and cognitive function in children

Abstract

Background

Chronic kidney disease (CKD) is commonly labelled as a silent killer associated with multiple comorbid conditions.

Purpose

To explore the impact of CKD on anthropometric profile, health-related quality of life (QoL) and cognitive function in children.

Patients and methods

A total of 150 children with CKD, age ranged from 8 to 12 years were assigned according to glomerular filtration rate into three groups of equal numbers; group I (stage 2 and 3), group II (stage 4) and group III (stage 5). Anthropometric measurements, QoL and cognitive function were measured and compared to 100 healthy age-matched groups.

Results

Compared with normal children, children with CKD showed a statistically significant short stature, low body weight, anaemia and poor QoL and cognitive impairments. Moreover, those at stage 5 yielded the worse scores.

Conclusion

CKD is associated with comorbid conditions as growth failure, anaemia, poor QoL performance and cognitive impairments.

References

  1. 1

    Schwartz GJ, Muñoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL. New equations to estimate GFR in children with CKD. J Am Soc Nephrol 2009; 20:629–637.

    Article  Google Scholar 

  2. 2

    Pirojsakul K, Mathews N, Mouin G. Chronic kidney disease in children: recent update. Open Urol Nephrol J 2015; 8(Suppl 3):117–123.

    Article  Google Scholar 

  3. 3

    Harambat J, van Stralen KJ, Kim JJ, Tizard EJ. Epidemiology of chronic kidney disease in children. Pediatr Nephrol 2012; 27:363–373.

    Article  Google Scholar 

  4. 4

    Sorensen EP, Sarnak MJ, Tighiouart H, Scott T, Giang LM, Kirkpatrick B, et al. The kidney disease quality of life cognitive function subscale and cognitive performance in maintenance hemodialysis patients. Am J Kidney Dis 2012; 60:417–426.

    Article  Google Scholar 

  5. 5

    Sarnak MJ, Tighiouart H, Scott TM, Lou KV, Sorensen EP, Giang LM, et al. Frequency of and risk factors for poor cognitive performance in hemodialysis patients. Neurology 2013; 80:471–480.

    Article  Google Scholar 

  6. 6

    Padilla J, Krasnoff J, Da Silva M, Hsu CY, Frassetto L, Johansen KL, Painter P. Physical functioning in patients with chronic kidney disease. J Nephrol 2008; 21:550–559.

    CAS  PubMed  Google Scholar 

  7. 7

    Varni JW, Burwinkle TM, Rapoff MA, Kamps JL, Olson N. The PedsQLTM in Pediatric Asthma: Reliability and Validity of the Pediatric Quality of Life InventoryTM Generic Core Scales and Asthma Module. J Behav Med 2004; 27:297–312.

    Article  Google Scholar 

  8. 8

    Ingulli EG, Mak RH. Growth in children with chronic kidney disease: role of nutrition, growth hormone, dialysis, and steroids. Curr Opin Pediatr 2014; 26:187–192.

    CAS  Article  Google Scholar 

  9. 9

    Rodig NM, McDermott KC, Schneider MF, Hotchkiss HM, Yadin O, Seikaly MG, et al. Growth in children with chronic kidney disease: a report from the Chronic Kidney Disease in Children Study. Pediatr Nephrol 2014; 29:1987–1995.

    Article  Google Scholar 

  10. 10

    Mahesh S, Kaskel F. Growth hormone axis in chronic kidney disease. Pediatr Nephrol 2008; 23:41–48.

    Article  Google Scholar 

  11. 11

    Wong CJ, Moxey-Mims M, Jerry-Fluker J, Warady BA, Furth SL. CKiD (CKD in children) prospective cohort study: a review of curent findings. Am J Kidney Dis 2012; 60:1002–1011.

    Article  Google Scholar 

  12. 12

    Gao T, Leonard MB, Zemel B, Kalkwarf HJ, Foster BJ. Interpretation of body mass index in children with CKD. Clin J Am Soc Nephrol 2012; 7:558–564.

    Article  Google Scholar 

  13. 13

    Foster BJ, McCauley L, Mak RH. Nutrition in infants and very young children with chronic kidney disease. Pediatr Nephrol 2012; 27:1427–1439.

    Article  Google Scholar 

  14. 14

    Rees L, Jones H. Nutritional management and growth in children with chronic kidney disease. Pediatr Nephrol 2013; 28:527–536.

    Article  Google Scholar 

  15. 15

    Noone D, Licht C. Chronic kidney disease: a new look at pathogenetic mechanisms and treatment options. Pediatr Nephrol 2014; 29:779–792.

    Article  Google Scholar 

  16. 16

    Mekahli D, Ledermann S, Gullett A, Rees L. Evaluation of quality of life by young adult survivors of severe chronic kidney disease in infancy. Pediatr Nephrol 2014; 29:1387–1393.

    Article  Google Scholar 

  17. 17

    Lima FF, Miranda RCV, Rossi e Silva RC, Monteiro HL, Yen LS, Fahur BS, Padulla SAT. Functional validation of patients in hemodialysis: Pré e pós-exercício. Medicine (Ribeirão Preto) 2013; 46:24–35.

    Article  Google Scholar 

  18. 18

    Nascimento LC, Coutinho EB, Silva KN. Effective physical exercise in chronic renal insufficiency. Fisioter Mov, Curitiba 2012; 25:231–239.

    Google Scholar 

  19. 19

    Teixeira CG, Duarte MC, Prado CM, Albuquerque EC, Andrade LB. Impact of chronic kidney disease on quality of life, lung function, and functional capacity. J Pediatr (Rio J) 2014; 90:580–586.

    Article  Google Scholar 

  20. 20

    Kurella-Tamura M, Xie D, Yaffe K, Cohen DL, Teal V, Kasner SE, et al. Vascular risk factors and cognitive impairment in chronic kidney disease: The Chronic Renal Insufficiency Cohort (CRIC) study. Clin J Am Soc Nephrol 2011; 6:248–256.

    Article  Google Scholar 

  21. 21

    Kalirao P, Pederson S, Foley RN, Kolste A, Tupper D, Zaun D, et al. Cognitive impairment inperitoneal dialysis patients. Am J Kidney Dis 2011; 57:612–620.

    Article  Google Scholar 

  22. 22

    Feng L, Yap KB, Yeoh LY, Ng TP. Kidney function and cognitive and functional decline in elderly adults: findings from the Singapore longitudinal aging study. J Am Geriatr Soc 2012; 60:1208–1214.

    Article  Google Scholar 

  23. 23

    Vianna HR, Soares CM, Tavares MS, Teixeira MM, Silva AC. Inflammation in chronic kidney disease: the role of cytokines. J Bras Nefrol 2011; 33:351–364.

    Article  Google Scholar 

  24. 24

    Troen AM, Scott TM, D’Anci KE, Moorthy D, Dobson B, Rogers G, et al. Cognitive dysfunction and depression in adult kidney transplant recipients: baseline findings from the FAVORIT Ancillary Cognitive Trial (FACT). J Ren Nutr 2012; 22:268–276.

    Article  Google Scholar 

  25. 25

    Bugnicourt JM, Godefroy O, Chillon JM, Choukroun G, Massy ZA. Cognitive disorders and dementia in CKD: the neglected kidney-brain axis. J Am Soc Nephrol 2013; 24:353–363.

    CAS  Article  Google Scholar 

  26. 26

    Gesualdo GD, Duarte JG, Zazzetta MS, Kusumota L, Say KG, Pavarini SCI, Orlandi FS. Cognitive impairment and chronic kidney disease: which links? Dement Neuropsychol 2017; 11:221–226.

    Article  Google Scholar 

  27. 27

    Cheng KC, Chen YL, Lai SW, Mou CH, Tsai PY, Sung FC. Patients with chronic kidney disease are at an elevated risk of dementia: a population-based cohort study in Taiwan. BMC Nephrol 2012; 13:129.

    Article  Google Scholar 

  28. 28

    Radić J, Ljutić D, Radić M, Kovaĉić V, Sain M, Curković KD. The possible impact of dialysis modality on cognitive function in chronic dialysis patients. Neth J Med 2010; 68:153–157.

    PubMed  Google Scholar 

  29. 29

    Nasser MT, Shawki S, El Shahawy Y, Sany D. Assessment of cognitive dysfunction in kidney disease. Afr J Nephrol 2010; 14:8–15.

    Google Scholar 

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Correspondence to Amira M. Abd El-Monem.

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Abd El-Monem, A. Impact of chronic kidney disease on anthropometric profile, health-related quality of life and cognitive function in children. Bull Fac Phys Ther 24, 26–31 (2019). https://doi.org/10.4103/bfpt.bfpt_15_18

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Keywords

  • chronic kidney disease
  • cognition
  • end-stage chronic kidney disease
  • quality of life
  • renal dialysis