- Original article
- Open access
- Published:
Effect of calcipotriol plus betamethasone dipropionate gel phonophoresis on psoriasis: a single-blind randomized controlled trial
Bulletin of Faculty of Physical Therapy volume 24, pages 57–65 (2019)
Abstract
Background
Psoriasis is a common, immune-mediated, inflammatory disease that can affect all aspects of a person’s life including esthetic appearance, relationships with others, and psychological, social, and physical functioning.
Objective
This study was conducted to investigate the therapeutic benefits of calcipotriol plus betamethasone dipropionate gel (Dovobet gel) phonophoresis in the treatment of plaque psoriasis.
Patients and methods
Forty patients with a moderate degree of psoriasis (localized psoriasis) were included, and their age ranged from 25 to 45 years. Patients were randomly assigned into two groups: the study group underwent calcipotriol plus betamethasone dipropionate gel phonophoresis and the control group underwent calcipotriol plus betamethasone dipropionate gel. All treatment interventions were applied at a frequency of three sessions per week for 8 weeks. Outcome measures were performed through ultrasound imaging system that was used to measure the thickness of the skin. The assessment was done before treatment and after 8 weeks of the treatment.
Results
There was a significant decrease in the skin thickness after treatment in the study group compared with that of control group (P<0.0001).
Conclusion
Calcipotriol plus betamethasone diproprionate phonophoresis is a useful therapeutic procedure in the treatment of plaque psoriasis.
References
Deng Y, Chang C, Lu Q. The inflammatory response in psoriasis: a comprehensive review. Clin Rev Allergy Immunol 2016; 50:377–389.
Lønnberg AS, Skov L, Skytthe A, Kyvik KO, Pedersen OB, Thomsen SF. Heritability of psoriasis in a large twin sample. Br J Dermatol 2013; 169:412–416.
Michalek IM, Loring B, John SM. A systematic review of the worldwide epidemiology of psoriasis. J Eur Acad Dermatol Venereol 2017; 31:205–212.
Takeshita J, Grewal S, Langan SM, Mehta NN, Ogdie A, Van Voorhees AS, Gelfand JM. Psoriasis and comorbid diseases epidemiology. J Am Acad Dermatol 2017; 76:377–390.
Nestle FO, Kaplan DH, Barker J. Psoriasis. N Engl J Med 2009; 361:496–509.
Naldi L, Mercuri SR. Smoking and psoriasis from epidemiology to pathomechanisms. J Invest Dermatol 2009; 129:2741–2743.
Menter A, Korman NJ, Elmets CA, Feldman SR, Gelfand JM, Gordon KB, et al. Guidelines of care for the management of psoriasis and psoriatic arthritis. Section 3. Guidelines of care for the management and treatment of psoriasis with topical therapies. J Am Acad Dermatol 2009; 60:643–659.
Vena GA, Galluccio A, Pezza M, Vestita M, Cassano N. Combined treatment with low-dose cyclosporine and calcipotriol/betamethasone dipropionate ointment for moderate-to-severe plaque psoriasis: a randomized controlled open-label study. J Dermatolog Treat 2012; 23:255–260.
National Institute for Health and Care Excellence (NICE). Clinical Guideline, 153. The assessment and management of psoriasis. October 2012. Available at: http://www.nice.org.uk/guidance/cg153. Accessed September 2017.
Menter A, Gold LS, Bukhalo M, Grekin S, Kempers S, Boyce BM, et al. Calcipotriene plus betamethasone dipropionate topical suspension for the treatment of mild to moderate psoriasis vulgaris on the body: a randomized, double-blind, vehicle-controlled trial. J Drugs Dermatol 2013; 12:92–98.
Langley RG, Gupta A, Papp K, Wexler D, Østerdal ML, Curčić D. Calcipotriol plus betamethasone dipropionate gel compared with tacalcitol ointment and the gel vehicle alone in patients with psoriasis vulgaris: a randomized, controlled clinical trial. Dermatology 2011; 222:148–156.
Segaert S, Røpke M. The biological rationale for use of vitamin Danalogues in combination with corticosteroids for the topical treatment of plaque psoriasis. J Drugs Dermatol 2013; 12:129–137.
Van de Kerkhof PC, Hoffmann V, Anstey A, Barnes L, Bolduc C, Reich K, et al. A new scalp formulation of calcipotriol plus betamethasone dipropionate compared with each of its active ingredients in the same vehicle for the treatment of scalp psoriasis: a randomized, double-blind, controlled trial. Br J Dermatol 2009; 160:170–176.
Sticherling M, Eicke C, Anger T. Practicability of combined treatment with calcipotriol/betamethasone gel (Daivobet gel) and improvement of the quality of life in patients with psoriasis. J Dtsch Dermatol Ges 2013; 11:420–427.
Lee KL, Zhou Y. Quantitative evaluation of sonophoresis efficiency and its dependence on sonication parameters and particle size. J Ultrasound Med 2015; 34:519–526.
Park D, Park H, Seo J, Lee S. Sonophoresis in transdermal drug delivery. Ultrasonics 2014; 54:56–65.
Akinbo S, Owoeye O, Adesegun S. Comparison of the therapeutic efficacy of diclofenac sodium and methyl salicylate phonophoresis in the management of knee osteoarthritis. Arch Rheumatol 2011; 26: 111–119.
Goraj-Szczypiorowska B, Zajac L, Skalska-Izdebska R. Evaluation of factors influencing the quality and efficacy of ultrasound and phonophoresis treatment. Ortop Traumatol Rehabil 2007; 9:449–458.
Srbely S. Ultrasound in the management of osteoarthritis: part I: a review of the current literature. J Can Chiropr Assoc 2008; 52:30–37.
Li M, Lan H, Huang Qiong YQ. Efficacy, safety and quality of life of topical calcipotriol betamethasone dipropionate in the treatment of psoriasis vulgaris. Chinese J New Drugs Clin Remed 2013. Available from: http://en.cnki.com.cn/Article_en/CJFDTOTAL-XYYL201306009.htm. [Accessed August 21, 2017].
Huang L, Li M, Huang Q, Yang QP, Zeng ZZ, Zhu XJ, et al. Calcipotriol betamethasone ointment in the treatment of psoriasis vulgaris: a randomized, double-blind, active-controlled, parallel group study. Chinese J Dermatol 2009; 42:691–694.
Saraceno R, Andreassi L, Ayala F, Bongiorno MR, Giannetti A, Lisi P, et al. Efficacy, safety and quality of life of calcipotriol/betamethasone dipropionate (Dovobet ®) versus calcipotriol (Daivonex ®) in the treatment of psoriasis vulgaris: a randomized, multicentre, clinical trial. J Dermatolog Treat 2007; 18:361–365.
Kragballe K, Noerrelund KL, Lui H, Ortonne JP, Wozel G, Uurasmaa T, et al. Efficacy of once-daily treatment regimens with calcipotriol/ betamethasone dipropionate ointment and calcipotriol ointment in psoriasis vulgaris. Br J Dermatol 2004; 150:1167–1173.
Papp KA, Guenther L, Boyden B, Larsen FG, Harvima RJ, Guilhou JJ, et al. Early onset of action and efficacy of a combination of calcipotriene and betamethasone dipropionate in the treatment of psoriasis. J Am Acad Dermatol 2003; 48: 48–54.
Douglas WS, Poulin Y, Decroix J, Ortonne JP, Mrowietz U, Gulliver W, et al. A new calcipotriol/betamethasone formulation with rapid onset of action was superior to monotherapy with betamethasone dipropionate or calcipotriol in psoriasis vulgaris. Acta Derm Venereol. 2002; 82:131–135.
Welkowitz J, Ewen RB, Cohen J. Introductory statistics for the behavioural sciences. 3rd ed. San Diego, CA: Harcourt Brace Jovanovich; 1982.
Doig GS, Simpson F. Randomization and allocation concealment: a practical guide for researchers. J Crit Care 2005; 20:187–193.
Leading a Digital Industrial Era − 2016 Annual Report’ (PDF). General Electric Company. https://www.ge.com/ar2016/assets/pdf/GE_AR16_Integrated_Summary_Report.pdf. Retrieved 2017-06-15.
El-Zawahry MB, Abdel El-Hameed El-Cheweikh HM, Abd-El-Rahman Ramadan S, Ahmed Bassiouny D, Mohamed Fawzy M. Ultrasound biomicroscopy in the diagnosis of skin diseases. Eur J Dermatol 2007; 17:469–475.
Vogt M, Helmut Ermert H. Development and evaluation of a high-frequency ultrasound-based system for in vivo strain imaging of the skin. IEEE Trans Ultrason Ferroelectr Freq Control 2005; 52:375–385.
Loyd V, Allen J. Compounding for phonophoresis. Secundum Artem 2005; 1:10–17.
Clark AR, Feldman SR, Jorizzo JL. Ultrasonic therapy for psoriasis. J Eur Acad Dermatol Venereol 1995; 4:58–61.
Author information
Authors and Affiliations
Corresponding author
Additional information
This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
Rights and permissions
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Wahba, E. Effect of calcipotriol plus betamethasone dipropionate gel phonophoresis on psoriasis: a single-blind randomized controlled trial. Bull Fac Phys Ther 24, 57–65 (2019). https://doi.org/10.4103/bfpt.bfpt_23_18
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.4103/bfpt.bfpt_23_18