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Effect of calcipotriol plus betamethasone dipropionate gel phonophoresis on psoriasis: a single-blind randomized controlled trial



Psoriasis is a common, immune-mediated, inflammatory disease that can affect all aspects of a person’s life including esthetic appearance, relationships with others, and psychological, social, and physical functioning.


This study was conducted to investigate the therapeutic benefits of calcipotriol plus betamethasone dipropionate gel (Dovobet gel) phonophoresis in the treatment of plaque psoriasis.

Patients and methods

Forty patients with a moderate degree of psoriasis (localized psoriasis) were included, and their age ranged from 25 to 45 years. Patients were randomly assigned into two groups: the study group underwent calcipotriol plus betamethasone dipropionate gel phonophoresis and the control group underwent calcipotriol plus betamethasone dipropionate gel. All treatment interventions were applied at a frequency of three sessions per week for 8 weeks. Outcome measures were performed through ultrasound imaging system that was used to measure the thickness of the skin. The assessment was done before treatment and after 8 weeks of the treatment.


There was a significant decrease in the skin thickness after treatment in the study group compared with that of control group (P<0.0001).


Calcipotriol plus betamethasone diproprionate phonophoresis is a useful therapeutic procedure in the treatment of plaque psoriasis.


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Correspondence to Ereny S. Wahba PhD.

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Wahba, E. Effect of calcipotriol plus betamethasone dipropionate gel phonophoresis on psoriasis: a single-blind randomized controlled trial. Bull Fac Phys Ther 24, 57–65 (2019).

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